• Our data for glucose and insulin tolerance tests indicate

  2022-08-05

  

  Our data for glucose and insulin tolerance tests indicate that niacin-induced hyperglycemia is proportional to the degree of insulin resistance induced, implying that there is deterioration in islet function with niacin treatment (McCulloch et al., 1991). In this regard, we have demonstrated, for th

• To overcome these limitations investigators have developed n

  2022-08-05

  

  To overcome these limitations, investigators have developed novel strategies for identifying and purifying gonadotropes from transgenic mouse models. For example, FSH-producing gonadotropes have been tagged in vivo with a transgenic cell surface antigen (H-2Kk) so that they can be purified in vitro

• Some studies show that testosterone may be involved in regul

  2022-08-05

  

  Some studies show that testosterone may be involved in regulating cell proliferation and its stimulating effect has been proved in castrated rats (Wainwright et al., 2011), but not in mice and meadow voles (Ormerod and Galea, 2003; Benice and Raber, 2010). However, the seasonal difference in cell pr

• Analysis of genomic neighborhoods has helped

  2022-08-05

  

  Analysis of genomic neighborhoods has helped resolve questions concerning the orthology of receptors for peptides similar to glucagon (Ng et al., 2010, Irwin and Prentice, 2011, Wang et al., 2012, Hwang et al., 2013). Using a diverse array of species with available genome sequence (see Fig. 4) the g

• These data suggest that the dehydration

  2022-08-05

  

  These data suggest that the dehydration of the SSRBCs induced by RANTES might result of an activation of the Gardos channel mediated by the chemokine receptor DARC. However, direct evidence of Gardos channel activation by chemokines in Duffy-positive SSRBCs leading to cell dehydration has not been e

• PF-3845 G quadruplex structures can be resolved by helicases

  2022-08-05

  

  G-quadruplex structures can be resolved by helicases. Consistently, many helicases are aberrantly expressed in cancer PF-3845 [47]. In this study, we correlated HOXC10 expression with that of all helicases using a microarray dataset derived from 759 breast cancer patients [36] and discovered that C

• To investigate an involvement of GPR and GPR in the

  2022-08-04

  

  To investigate an involvement of GPR120 and GPR40 in the enhancement of cell motile activity of MG-63 cells, highly migratory (MG63-R7) PD173955 were established from MG-63 cells (Fig. 2A). The expression level of GPR120 gene was significantly higher in MG63-R7 cells than in MG-63 cells, while no ch

• Our observation of LPS induced increase in the sensitivity

  2022-08-04

  

  Our observation of LPS-induced increase in the sensitivity of cultured endothelium-intact coronary Cryptochlorogenic acid towards stimulation with selective ETB receptor agonist (S6c) could be explained by activation of TLRs receptors located on the endothelium of rat coronary arteries. However, the

• br Materials and methods br

  2022-08-04

  

  Materials and methods Results Discussion The COMPASS family of histone methyltransferases exhibits HMT activity towards histone 3 lysine 4 residue with KMT2F and KMT2G being the major H3K4 methylases (Shilatifard, 2006). They play an important role in the formation and progression of leukem

• Some SNPs have been identified for HRH

  2022-08-04

  

  Some SNPs have been identified for HRH in cancer (Table 4). Looking into breast cancer research, H4 receptor polymorphisms have been recently associated with the malignancy of the disease. This was evidenced upon the analysis of genotypes and haplotypes of a Chinese Han population; this study showed

• br STAR Methods br Acknowledgments

  2022-08-04

  

  STAR★Methods Acknowledgments We thank the TCGA PanCanAtlas Analysis Working Group. This study was supported in part by grants from the NIH (CA175486 and CA209851 to H.L., CA217842 to G.B.M., and CCSG grant CA016672); a grant from the Cancer Prevention and Research Institute of Texas (RP140462

• br HER proto oncogene The

  2022-08-04

  

  HER2 proto-oncogene The erbB2 gene, located on the short arm of chromosome 17, was discovered and cloned in 1983 (Fig. 1) (Sato et al., 1983). The product of this gene, HER2, is a transmembrane glycoprotein of 185 KDa that consists of three main domains: an extracellular, a transmembrane and an i

• The overall characteristic of RNA profile of Leydig

  2022-08-04

  

  The overall characteristic of RNA profile of Leydig cell is still a mystery. Variation in total RNA will cause subsequent difference in protein expression and phenotypic modulation [16]. In this study, we used a murine nicotine exposure model coupled with next generation RNA sequencing (NGS) and fou

• Despite the association with asthma it is not surprising tha

  2022-08-04

  

  Despite the association with asthma, it is not surprising that we did not find a relation between the percent predicted FEV1 and SNPs in GSNOR. FEV1 measured on a routine clinic visit is likely to be normal in most asthmatic children. FEV1 in children reflects a complex mix of factors in the growth

• SF1670 With this goal in mind we proceeded to explore the

  2022-08-04

  

  With this goal in mind, we proceeded to explore the C5-heteroaryl class of pyrazole-acids. Initial efforts, focused on a thiophene replacement, demonstrated little improvement. The 2-thiophene derivative (0.25μM and 0.24μM), a surrogate to the phenyl moiety, demonstrated only a modest boost in activ

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